These chromosomes are made up of thousands of shorter segments of DNA, called genes. These instructions are stored inside each of your cells, distributed among 46 long structures called chromosomes. Each strand has a backbone made of alternating sugar (deoxyribose) and phosphate groups. A DNA molecule is made up of two linked strands that wind around each other to resemble a twisted ladder in a helix-like shape. Hence, the algorithm, which is currently implemented within a new computer program NASDAC (Nucleic Acids: Structure, Dynamics and Conformation), should have generally applicability to the computation of DNA structures. What are the three parts of a nucleotide which parts make up the backbone of a DNA strand five carbon sugar aka deoxyribose. It stores instructions for making other large molecules, called proteins. Double helix, as related to genomics, is a term used to describe the physical structure of DNA. Regardless of the conformational complexity of these structures, we are able to compute backbone conformations for each structure.
#BACKBONE OF DNA SERIES#
To illustrate the utility and properties of the algorithm, we have applied it to a series of experimental DNA structures. The algorithm is also able to detect repeating segment conformations that arise in structures containing geometrically repeating dinucleotide steps. Initial computation of allowable segment conformations of a strand is followed by the determination of continuous backbone solutions for the strand, beginning at the 3'-end. The Sugar- phosphate backbone is made up of Sugar (deoxyribose) and Phosphate. A given 'allowed' conformation of a backbone segment is determined based on its compatibility with the base positions and with the position of the preceding backbone segment. What does DNA consists of DNA consist of a sugar- phosphate backbone and nitrogenous bases. Following exhaustive searching of sugar conformations, each segment conformation is reduced to a single vector, defined by a specific distance, angle and torsion angle, that allows calculation of the O(1)' position. The DNA molecule acts as an information storage medium for the cell. The backbone is spatially arranged in the form of a double helix, with base pairs connecting the two sugar-phosphate strands.
Computation of the possible segment conformations is achieved by the initial creation of a fragment library, with each fragment representing a set of bond lengths, bond angles and torsion angles. The backbone of DNA is the portion which provides structural support to the two strands and is made up of alternating sugar and phosphate groups while. The backbone of the DNA molecule is made of a repeated pattern containing a sugar called deoxyribose and a phosphate group. The algorithm involves the sequential computation of 2'-deoxyribose and phosphodiester conformers (collectively referred to as a backbone 'segment'), beginning at the 5'-end of a DNA strand. We present an algorithm for the computation of 2'-deoxyribose-phosphodiester backbone conformations that are stereochemically compatible with a given arrangement of nucleic acid bases in a DNA structure.
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